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請說明酸鹼值-分配假說(pH-partition hypothesis)及其在藥劑及生物藥劑學上之應用。(10分)
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P.VK 高三上 (2017/07/05 01:21)
pH-partition hypothesis: The pH-partitio...


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P.VK 高三上 (2017/07/05 01:20)
pH-partition hypothesis: The pH-partition hypothesis was proposed by Brodie and his associates (in 1957) to explain the influence of GI pH and drug pKa on the extent of drug transfer or drug absorption. {1} According to this theory for drug compounds of molecular weight greater than 100 and those which are primarily transported across the membrane by passive diffusion, the process of absorption is governed by three important factors like:{1} 1.The dissociation constant i.e pKa of the drug. 2.The lipid solubility of the unionised drug i.e partition coefficient (Ko/w). 3.pH at the absorption sit...
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