110 年 - 110長庚大學_碩士班招生考試_生物醫學研究所：翻譯題#101183　

二、翻譯題(請標明題號並於答案纸上依序作答)
Please translate the 10 underlined words(翻譯下列10個有底線單字):
The centromere is essential in cell division but its exact function and   (1) composition   has eluded
researchers for many years. A novel PCR-based approach may force the centromere to give up its final
secrets. The centromere   (2) comprises   approximately 5% of the human genome, is at the center of every chromosome as the link between sister chromatids and plays an essential role in cell division by      (3)facilitating    spindle attachment and    (4) ensuring   proper chromosome segregation. However, the study of centromeres has been made difficult by its repetitive DNA sequence - leading to its    (5) reputation    as the final frontier of DNA. Centromeres are comprised of long repeating sequences of DNA named alpha satellite DNA. The sequences within the repeats are similar or even identical, each comprising of potentially 170 bases, hence making ordering the sequences difficult. Traditional DNA sequencing   (6) chops    up a DNA strand into shorter parts, which are then read and    (7) assembled    back together. "The problem with centromeres is all the pieces look the same. It'll be like putting together a puzzle of the Sahara Desert,"commented Beth Sullivan, a molecular biologist at Duke University School of Medicine (NC, USA). Whilst the human genome project may have bcen   (8) declared    complete 15 years ago, there are still gaps. This is mainly comprised of centromeric DNA as the technologies at the time were not (9) sophisticated enough to allow the sequencing of this   (10) portion   . However, recent developments in this field have now pioneered technologies which are sophisticated enough.