【已刪除】67 下列何種藥物，於戰爭時被用於預防有機磷化學武器藥物不可逆結合至 cholinesterase？
(A)atropine
(B)pralidoxime
(C)pyridostigmine
(D)trospium

有機磷會不可逆的和 acetylcholinesterase 結合，導致過多的 Ache  和 M receptor 作用，造成縮瞳、流淚、氣管痙攣等等的作用。這時候如果有一個藥物可以可逆的與 acetylcholinesterase  結合，就達成阻止有機磷的目的。

 Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome.

Soman is an organophosphorus nerve agent with a mechanism of action similar to Tabun. Nerve agents inhibit acetylcholine esterase (AChE) by forming an adduct with the enzyme via a serine residue on that enzyme.  

Trospium chloride is a muscarinic antagonist. Trospium chloride blocks the effect of acetylcholine on muscarinic receptors organs that are responsive to the compounds, including the bladder.^[2] Its parasympatholytic action relaxes the smooth muscle in the bladder.^[3] Receptor assays showed that trospium chloride has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses