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With the development of modern medical science, people worldwide are living longer. Marketers try to 16 every opportunity to sell remedies and devices that they claim can enhance memory and other cognitive functions and perhaps 17 dementia as people age. Among them are “all-natural” herbal supplements like Luminene, brain-training games on computers and smartphones, and all manner of puzzles, including crosswords, sudoku and jigsaw, that give the brain a workout, 18 a sedentary one. Unfortunately, few such potions and gizmos have been proven to have a meaningful, sustainable benefit beyond 19 the pockets of their sellers. Before you invest in them, you’d better be wise to look for well-designed, placebo-controlled studies that 20 to their ability to promote a youthful memory and other cognitive functions.