專技 - 調劑學與臨床藥學題庫下載題庫

上一題
下列何者與allopurinol併用時須大幅降低劑量？
【題組】78.承上題，該藥品須降低劑量的原因為下列何種酵素被抑制？
(A) CYP3A4
(B) monoamine oxidase
(C) xanthine oxidase
(D) aldehyde dehydrogenase

答案：C
難度： 非常簡單
最佳解!
となりのトトロ 國二下 (2016/05/30)
A) CYP3A4 肝酵素(常見藥物交惡作用)B) Monoamine Oxidase Inhibitors, MAOIs(單胺氧化酶抑制) 為一類抑制單胺氧化酶作用的藥物。該類藥品在抑鬱症的治療中已有很長的一段歷史。單胺是指Norepinephrine(NE)、Epinephrine、Serotonine(5-HT)、TyramineC) 痛風用藥Allopurinol、Febuxo.....看完整詳解
2F
Chelsea Chen 高二下 (2018/07/18)

AZA代謝途徑包括XO，與allopurinol 並用會增加AZA 濃度


the metabolism of mercaptopurine (MP), or its prodrug azathioprine (AZA), occurs via 3 primary pathways: oxidation to inactive thiouric acid catalyzed by xanthine oxidase (XO); methylation to inactive methyl-mercaptopurine catalyzed by thiopurine S-methyl transferase (TPMT); and activation to thioguanine nucleotides in a process initiated by hypoxanthine-guanine phosphoribosyl transferase.

Inhibition of XO by allopurinol may increase systemic MP exposure and toxicity, particularly via inhibition of its presystemic metabolism.

US prescribing in...


查看完整內容
3F
簡伯丞 大一下 (2019/06/06)

Allopurinol + azathioprine

Allopurinol，因抑制Xanthine Oxidase，可導致Azathioprine衍生物濃度上升


下列何者與allopurinol併用時須大幅降低劑量？【題組】78.承上題，該藥..-阿摩線上測驗