27. Which of the following description about autonomic, endocrine and immune interactions in pain
is correct?
(A) Signaling from the immune system to the CNS via vagal afferents and possibly small-diameter
afferents innervating somatic tissues to induce sickness behavior
(B) Modulation of the immune system and the inflammatory response by CNS circuits that control
the production and release of neuroendocrine hormonal mediators in the sympathoadrenal
stress axis
(C) Coupling of the sensory nociceptive and sympathetic efferent components of the peripheral
nervous system in the setting of inflammation and nerve injury to produce sympathetically
maintained pain
(D) All of above
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