專技 - 調劑學與臨床藥學題庫下載題庫

There are no antibiotics that have been approved by the US Food and Drug Administration for intraventricular use. The greatest clinical experience has been with vancomycin and gentamicin;

Recommended dosages of antimicrobial agents administered by the intraventricular route
Amikacin Colistin
Daptomycin Gentamicin
Polymyxin B Quinupristin/dalfopristin
Tobramycin Vancomycin

uptodate

Intrathecal administration of antibiotics can be considered in patients with nosocomial meningitis (eg, meningitis developing after neurosurgery or placement of an external ventricular catheter) that does not respond to IV antibiotics. Although the FDA has not approved any antibiotics for intraventricular use, vancomycin and gentamicin are often used in this setting. Other agents used intrathecally include amikacin, polymyxin B, and colistin.