4.It has been reported that long-term hormone replacement therapy (HRT) in women with menopause
may increase the risk of cancer, possibly because
(A) Hormone opens channels in the membrane for other substances to enter
(B) Hormone receptor opens channels in the nuclear envelope for cytoplasmic molecules to enter (C) Hormone enables water-soluble molecules to diffuse across membranes
(D) Hormone-receptor complex regulates gene transcription in the nucleus
(E) Hormone-receptor complex transfers the phosphate groups from ATP
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