專技 - 藥物治療學題庫下載題庫

sitagliptin（DPP4 inhibitor）：

Metabolism （肝）
Metabolism by CYP3A4 and, to a lesser degree, CYP2C8 is a minor pathway in the Cl of sitagliptin.

Elimination （主要為腎）
Terminal t ½ is approximately 12.4 h. Approximately 13% is excreted in feces and 87% in urine via active tubular secretion (79% as unchanged drug). Sitagliptin is a substrate for organic anion transport.

副作用：鼻咽炎、上呼吸道感染、腹瀉、噁心和頭痛。