專技 - 藥物治療學題庫下載題庫

脫水導致分布體積減少、減少清除率
To study the effect of dehydration on gentamicin (G) kinetics, a group of rats was deprived of water for 4 days and then received a single i.v. dose of 3 mg/kg of G. Compared to control rats, the plasma and tissue concentration of G in dehydrated rats were increased and the elimination rate of the drug decreased. Higher G concentrations were found in plasma, spleen, renal cortex and medulla. These changes in G disposition consisted in a decrease of 33 and 22% of the apparentvolume of distribution of the peripheral and central compartments, respectiv...
查看完整內容

脫水導致分布體積減少、減少清除率

To study the effect of dehydration on gentamicin (G) kinetics, a group of rats was deprived of

water for 4 days and then received a single i.v. dose of 3 mg/kg of G. Compared to control rats, the

plasma and tissue concentration of G in dehydrated rats were increased and the elimination rate of

the drug decreased. Higher G concentrations were found in plasma, spleen, renal cortex and

medulla. These changes in G disposition consisted in a decrease of 33 and 22% of the apparentvolume of distribution of the peripheral and central compartments,

respectively, and, furthermore,in a decrease of 40% in the G apparent

total body clearance. 

https://pubmed.ncbi.nlm.nih.gov/7241381/