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61 下列何種藥物最不適用來治療高劑量 barbiturate 的禁斷作用(withdrawal symptoms)？
(A) alprazolam
(B) buspirone
(C) triazolam
(D) lorazepam

專技 - 藥理學與藥物化學- 92 年 - 92-2 專技高考_藥師：藥理學#10730

答案：B
難度： 簡單

討論
私人筆記( 0 )

	1F Bryan 國三上 (2014/04/05) The mechanism of action of Buspirone is unknown. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics.Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models. 檢舉
	2F Bryan 國三上 (2014/04/05) In vitropreclinical studies have shown that Buspirone has a high affinity for serotonin (5-HT1A) receptors. 檢舉
	3F 菜餅大三上 (2023/01/12) Buspirone ： 1.onset 慢，用在廣泛性焦慮。 2.是5HT1A部分致效劑，跟GABA無關，不能治高劑量 barbiturate 的禁斷作用。檢舉

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