69 下列何者與 mercaptopurine 有嚴重的交互作用? (A) ..-阿摩線上測驗
1F Swear 幼兒園下 (2015/02/03)
Severe bone marrow suppression and other toxicity have been associated with concomitant use of allopurinol and mercaptopurine (6-MP) or azathioprine. Allopurinol inhibition of 6-MP first-pass metabolism via hepatic or intestinal xanthine oxidase, the enzyme that catalyzes the inactivation of 6-MP. |