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王老先生接受腎臟移植後併用 cyclosporine 與 prednisone 治療,四個月後檢驗血脂,
【題組】67 有關王老先生血脂異常之處置,下列口服處方中,何者是首選?
(A) Cholestyramine 4 g tid
(B) Lovastatin 80 mg hs
(C) Niacin ER 1 g hs
(D) Pravastatin 20 mg qd


答案:D
難度: 適中
最佳解!
Swear 幼兒園下 (2015/05/30)
口服Pravastatin,主要透腸肝循環.....看完整詳解
3F
我94鴨嘴獸 高二上 (2017/07/01)

Pravastatin不經過CYP★★,★★★★...



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4F
1m 大一上 (2018/07/06)

Pravastatin is the statin of choice in patients on cyclosporine.

uptodate還特地把上述列成單獨一點!!

The risk is substantially increased for most statins extensively metabolized by cytochrome P450 3A4 (lovastatin, simvastatin and to a lesser extent atorvastatin) with concurrent therapy with drugs that interfere with CYP3A4 

Pravastatin, fluvastatin, rosuvastatin, and pitavastatin are preferred when concurrent therapy with a strong inhibitor of CYP3A4 cannot be avoided.

5F
幫忙發口罩囉 大二下 (2020/07/02)

pravastatin不被CYP450代謝,為器官移植後引起的高血脂症首選用藥

from建材課本

王老先生接受腎臟移植後併用 cyclosporine 與 prednisone ..-阿摩線上測驗