試題詳解

35. Ted further studied axon transport by knocking down various genes using small hairpin RNA (shRNA). He found that when he knocked down protein X, synaptic vesicles accumulated at the axon terminal. This phenotype could be abolished by further knocking down another protein, Y. When Ted knocked down both X and Y, all the synaptic vesicles accumulated in the cell body. Assume that X and Y are both proteins involved in motor activity. Which of the following are correct?
(A) Protein X could be one of the components in a high molecular weight complex that mediates antegrade axon transport
(B) Y may have a microtubule-binding domain
(C) Treating the cells with cytochalasin, an actin-depolymerizing drug, should produce phenotypes similar to those of Y knockdown
(D) X moves in the same direction as the underlying cytoskeleton growth, whereas Y moves in the opposite direction
(E) Normal function of Y requires ATP hydrolysis