複選題

38. Germinal center reactions are critical for mounting the humoral immune responses. Which of the following statements are NOT correct? (Select all that apply.)
(A) Somatic hypermutation introduces mutations to the constant region of the immunoglobulin
(B) AID (Activation-Induced Cytidine Deaminase) is essential for class switching and somatic hypermutation
(C) Follicular dendritic cells (FDC) present short peptides to helper T cells that then activate B cells
(D) Class switching requires interactions between germinal center B cells and follicular helper T  cells
(E) Thymus-Independent (TI) stimulation events generate germinal center responses