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Dosing: Renal Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. The following adjustments have been suggested:

CrCl <50 mL/minute and continuous renal replacement therapy (CRRT): No dosage adjustment necessary (Aronoff 2007).

Hemodialysis:

Administer standard dose following hemodialysis on dialysis days (Janus 2010).

Administer 50% of standard dose following hemodialysis (Aronoff 2007).

Half-life elimination: Following bolus infusion: 8 to 20 minute...

Dosing: Renal Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. The following adjustments have been suggested:

CrCl <50 mL/minute and continuous renal replacement therapy (CRRT): No dosage adjustment necessary (Aronoff 2007).

Hemodialysis:

Administer standard dose following hemodialysis on dialysis days (Janus 2010).

Administer 50% of standard dose following hemodialysis (Aronoff 2007).

Half-life elimination: Following bolus infusion: 8 to 20 minutes