11. Which of the following statements about the CRISPER-Cas9 is wrong?
(A) One of the great genome-editing tools
(B) A naturally occurred system in yeast
(C) A guide RNA is needed
(D) With the ability to change an organism's DNA
(E) More efficient than other existing genome-editing methods

7. Which of the statements about nucleus is NOT CORRECT? (A) Structures as a double-membrane compartment (B) Containing bulk of genome (C) RNA transcription (D) DNA maintenance (E) Exosome secretion

8. What is the primary role of DNA methylation in DNA replication of E. coli? (A) The hemimethylated origin region of DNA replication are inactive for initiation (B) The methylated CpG island is important for DNA initiation of DNA replication (C) The methylation of DNA is important for restriction-modification systems (D) The methylation of origin region containing GATC sequences is important for the regulation of DNA priming (E) DNA methylation has no function in DNA replication

9. The central dogma of molecular biology including two processes: transcription and _____? (A) Reverse transcription (B) Degradation (C) Replication (D) Translation (E) Reverse replication

10. Which of the following ones does NOT happen in mRNA processing? (A) Splicing (B) Editing (C) Polyadenylation (D) All of the above (E) None of the above

12.How many of the 64 possible triplets together encode stop codons? (A) 1 (B) 2 (C) 3 (D) 5 (E) 10

13.Which promoter elements of the following RNA polymerase(s) possess TATA box? (A) RNA polymerase I, II and III (B) RNA Polymerase II and III (C) RNA polymerase I (D) RNA polymerase II (E) RNA polymerase III

14. Which of the following statements is NOT CORRECT for DNA topoisomerases? (A) DNA topoisomerases can cleave DNA backbone at phosphodiester bond (B) Only participate enzymatically in overwinding, knotting and catenation of DNA (C) Relive the torsion stresses associated with DNA replication and transcription elongation (D) Both type I and II topoisomerase change the linking number of DNA (E) Human topoisomerase I is the antigen recognized by Anti-Scl-70 in scleroderma

15.Typically, protein-protein can be detected by yeast two-hybrid and co-immunoprecipitation assays as well as which of the following methods? (A) RNAi screening technology (B) Yeast one-hybrid (C) Gel mobility shift assay (D) Farwestern blotting analysis (E) CRISPER-Cas9 technology

16. Which one of the statements about amino acid is NOT TURE? (A) The essential amino acid is due to that they can not be produced from other compounds of human body (B) There are 10 proteinogenic amino acid are called "essential" (C) Amino acids have both the amine and the carboxylic acid groups attached to the first (alpha-) carbon. (D) There are about 500 naturally occurring amino acid (E) Only 20 amino acid appear in the genetic code

17. Which one of the statements about heterochromatin is NOT CORRECT? (A) It is often tightly packed form of DNA (B) There are facultative heterochromatin and constitutive heterochromatin and both play a role in the expression of genes (C) Heterchromatin has been associated with the di- and tri-methylation of H3K19 in certain portions of the genome (D) Euchromatin and heterochromatin could be distinguished cytologically by how intensively they are stained, and typically heterochromatin stains intensely while euchromatin is less intense (E) Heterochromatin consists mainly of genetically inactive satellite sequences