試題詳解

12. Polylysine is a random coil when the pH is less than 11, but it forms an a-helix if the pH is raised above 12. This happens because
(A) The ε-NH₂ group is protonated into ε-NH₃⁺ at pH 12 and the charges stabilize the a- helix structure.
(B) The pKa of ε-NH₂ group is 12 and the partially protonated amino groups stabilize the a- helix structure.
(C) The high concentration of OH- at pH 12 reduces the effective positive charges on the ε-NH3+ groups and results in less electrostatic repulsion between R groups.
(D) The  ε-NH₃⁺ groups are titrated to produce neutral NH2 groups, which eliminate electrostatic repulsions between R groups.
(E) The ε-NH₂ becomes negatively charged ε-NH^- which stabilize thea-helix structure.