12. Which isotype of immunoglobulin sensitizes NK cells?
(A)IgA
(B) IgD
(C) IgE
(D) IgG
(E) IgM

13. Which is NOT the event of cellular immune responses? (A) Antibody-mediated cellular cytotoxicity (ADCC) (B) Cytokine secretion (C) Granzyme/perforin-mediated killing (D) Neutralization (E) Phagocytosis.

複選題14. Which one of following features is the characteristic of class II MHC molecule? (A) Accommodates peptides of 10-30 residues (B) CD4 binds mainly to the o1 domain (C) Locations of polymorpbic residues are a1 and o2 domains (D) Nomenclatures are HLA-A, -B, -C in human (E) Polypeptide chains are a and Bz-microglobulin.

15. Which one of following features is the characteristic of class II MHC pathway of antigen processing and presentation? (A) B1, 32 and B5 subunits of proteasomes are responsible for protein degradation (B) CD8+ TI cells are responsive T cells (C) Endoplasmic reticulum (ER) is the site of peptide loading to MHC. (D) Late endosomes and lysosomes are the site of antigen degradation (E) TAP1/2 molecules are involved in peptide transport and loading.

複選題16. Which one of followings is a component of class II MHC pathway of antigen processing and presentation? (A) Aminopeptidase ERAAP (B) HLA-DM (C) LMP7 (D) MECL-1 (E) Tapasin.

17. Which one of the following factors is involved in negative selection of T cell development? (A) CD8 co-receptor (B) Hassall's corpuscle (C) Macrophage in the medulla (D) MHC class I/II (E) Peptides on MHC class III.

18. Which one of the following properties is the outcome of both pre-BCR and pre-TCR signaling? (A) Allelic exclusion (B) Class switch recombination (CSR) (C) Positive selection (D) Shut off pTo transcription (E) Stimulation of k chain recombination.

19. Which one of the following defects impairs T cell development but NOT B cell development? (A) ADA deficiency (B) Btk deficiency (C) NFAT deficiency (D) RAG deficiency (E) TAP-1 deficiency.

20. Which one of the following properties is the feature of B-1 cells? (A) IL-7 dependent (B) Main secretion is IgM and first produced at fetus (C) Mode of renewal is long-lived (D) Primary location is spleen (E) Somatic hypermutation is high.

21. Which one of following antigens is Tl-1 antigen? (A) Bacterial lipopolysaccharide (B) Dextran (C) Diphtheria toxin (D) Preumococcal polysaccharide (E) Viral hemagglutinin.

22. Which one of following transcription factors determines the CD4 commitment in the thymus? (A) Bcll1b (B) Ets-1 (C) GATA2 (D) Runx3 (E) ThPOK.

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