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 Increasing  expression  of  the  anti-inflammatory  enzyme  indoleamine 2,3-dioxygenase (IDO) by treatment with IFN-γ or by unmethylated CpG DNA can induce the generation or activation of Treg  cells. 

Tumors can produce enzymes that act to suppress local immune responses. The enzyme indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan, an essential amino acid, in order to produce the immuno suppressive metabolite  kynurenine.  IDO  seems  to  function  in  maintaining  a  balance between  immune  responses  and  tolerance  during  infections,  but  can  be indu...

 Increasing  expression  of  the  anti-inflammatory  enzyme  indoleamine 2,3-dioxygenase (IDO) by treatment with IFN-γ or by unmethylated CpG DNA can induce the generation or activation of Treg  cells. 

Tumors can produce enzymes that act to suppress local immune responses. The enzyme indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan, an essential amino acid, in order to produce the immuno suppressive metabolite  kynurenine.  IDO  seems  to  function  in  maintaining  a  balance between  immune  responses  and  tolerance  during  infections,  but  can  be induced during the equilibrium phase of tumor development.