14. TAP1/2 deficiency

15. Which one of following molecules is expressed in the medulla of the thymus and promotes the expression of proteins normally expressed in peripheral tissues? (A) AID (B) AIRE (C) ID-2 (D)IL-2 (E) TECK

16. Which one of following transcription factors determines the CD4 or CD8 commitment in the thymus? (A) Bclllb (B) KLF2 (C) GATA3 (D)Runx1 (E) ThPOK

17. Which one of following receptors regulates the release of immature B cells from bone marrow into the circulation? (A) CCR5 (B) CXCR2 (C) IL-7R (D)S1PR1 (E) TLR

18. Which one of following strategy is NOT used by extracellular bacteria to subvert the host immune system? (A) Antigenic variation (B) Inhibition of opsonization (C) Inhibition of BCR/TCR expression (D) Inhibition of microbial-associated molecular patterns (MAMPs) (E) Resistance to antimicrobial peptides (AMPs)

19. Autoinflammatory diseases indicate the failure of normal mechanisms that limit inflammation and it can lead inflammation without the infection. Which one of followings is an autoinflammatory discase? (A) Wiskott-Aidrich syndrome (B) Severe combined immunodeficiency (C) MHC class I deficiency (D) Familial Mediterranean fever (FMF) (E) DiGeorge's syndrome

20. The name given to a fully activated and differentiated B cell that secretes antibody is (B) antigen-presenting cell (C) plasma cell (D) hematopojetic cell (E) secretory cell (A) T cell

21. Which of the following statements regarding immunoglobulin light chains is correct? (A) k (kappa) associates with only particular heavy-chain isotypes (B) Agiven antibody may contain just k (kappa), or justλ (lambda), or both (C) Most antibodies in humans contain 2. (lambda) light chains (D) There is no functional difference between x (kappa) andλ (lambda) (E) Light chains possess only framew work regions, not hypervariable regions

22. The process of_________ results in the amplification of particular B cells with specificity for antigen: (A) germline recombination (B) somatic recombination (C) clonal selection (D) antigen processing (E) antigen presentation

23. 'T cells recognize antigen when the antigen (A) is internalized by T celis via phagocytosis and subsequently binds to T-cell receptors in the endoplasmic reticulum. (B) forms a complex with membrane-bound MHC molecules on another host-derived cell (C) is presented on the surface of a B cell on membrane-bound immunoglobulins (D) forms a complex with membrane-bound MHC molecules on the T cell (E) bears epitopes derived from proteins, carbohydrates, and lipids

24. If a non-professional antigen-presenting cell that lacks co-stimulatory molecules presents peptide:MHC complexes to a T cell specific for that peptide, then_________. (A) the T cell delivers a signal to the non-professional antigen-presenting cell to activate the expression of co-stimulatory molecules (B) the T cell begins to express the α (alpha) chain of the IIL-2 receptor (C) the T cell differentiates into a THI cell (D) T-cell tolerance e occurs as a result of anergy (E) the Tcell is more heavily reliant on signals transmitted through CD4 or CD8 in order to become activated

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