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高普考/三四等/高員級◆英文題庫下載題庫

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Gene therapy may be in its infancy, but great hopes for its potential to treat everything from cancer to Alzheimer’s to heart disease are forcing it to grow up fast. After two decades of lab research, gene treatments are increasingly making their way into human clinical trials. The bulk of research so far has focused on getting a gene to its destination and coaxing it to turn on once inside a cell. On their own, genes can’t pass through cell membranes, and much effort has been spent to trick cells into accepting foreign genes. The most efficient couriers are so-called viral vectors: viruses whose genomes have been swapped out for therapeutic genes. Like Trojan horses, they slip genes into target cells undetected. But as scientists are learning, there is no safe way to hijack a virus. The vectors sometimes trigger immune reactions. And once the genes are inside a cell, there is no way to be sure they will function as intended. Case in point: a Paris gene therapy trial to treat SCIDs, or the “bubble boy disease,” restored immune function in nine of 10 patients. But it was later revealed that two of them had developed leukemia.
【題組】What is the main idea of the passage?
(A) After two decades of lab research, gene therapy in humans has been successful in treating everything from cancer to Alzheimer’s to heart disease.
(B) A lot of research in gene therapy has focused on getting a gene to its destination and coaxing it to turn on once inside a cell.
(C) Although research has been done on how gene therapy can help treat serious diseases, such a treatment may cause irreversible side effects and unknown consequences.
(D) Viral vectors like Trojan horses slip genes into target cells undetected.

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難度： 簡單
1F
Chun Jen Wan 高二上 (2012/02/15)
基因療法可能是處於起步階段，但其潛在的治療從癌症到老年癡呆症的心臟疾病寄予厚望，迫使其快速成長起來。經過二十年的實驗室研究，基因治療被越來越多地進入人體臨床試驗。大量研究，迄今一直專注於得到一個基因，它的目的地，哄它把細胞內的一次。對自己，基因不能穿過細胞膜，已經花了很多努力，誘使細胞接受外源基因。最有效的信使是所謂的病毒載體的基因治療已經交換了基因組的病毒。特洛伊木馬一樣，他們陷入靶細胞未被發現的基因。但是，科學家們正在學習，有沒有安全的方式來劫持病毒。向量有時會引發免疫反應。一旦細胞內的基因，也沒有辦法，以確保他們將充當。案例分析：巴黎的基因治療試驗治療SCIDs，或“泡泡男孩病”，恢復免疫功能的10例9。但後來發現，其中兩人已患上了白血病。


Gene therapy may be in its infancy, but ..-阿摩線上測驗