19. Based on the gene and protein sequences that follow, what type of mutation-polypeptide effect has occurred? Normal gene: ATGGCCGGCACCGAAAGAGACC Mutated gene: ATGGCCGGCCCGAAAGAGACC Normal protein: Met-Ala-Gly-Thr-Glu-Arg-Asp Mutated protein: Met-Ala-Gly-Pro-Lys-Glu-Thr
(A)nucleotide deletion-nonsense
(B)nucleotide deletion-missense
(C)nucleotide deletion-frameshift
(D) nucleotide insertion- missense
(E)nucleotide insertion-frameshift

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統計: A(1), B(17), C(98), D(9), E(22) #938814

詳解 (共 2 筆)

#2553716
Normal gene:   ATGGC...
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#5513968
框移突變(Frameshift mutation)又稱移碼突變,為一種基因突變,由非三的倍數個核苷酸的插入(insertion)或刪除(deletion)造成,因基因表現時密碼子是由三個核苷酸組成,此類插入或刪除會改變閱讀框架,進而使mRNA在此突變以後轉譯出完全不同的蛋白質。框移突變在開放閱讀框越上游的區域發生,對蛋白質的影響越大,且因框移突變可能會改變終止密碼子出現的位置,也會改變轉譯出蛋白質的大小,一般會使其完全失去功能
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