3. 某位 CKD stage 5 的病人,[Ca] 8.7 mg/dL, [..-阿摩線上測驗
. 大三上 (2021/05/22): B: increase FGF-23 FGF-23 is part of a family of phosphatonins that promotes renal phosphate excretion. FGF-23, secreted by osteocytes, increase early in the course of CKD, even before phosphate retention and hyperphosphatemia. FGF-23 may defend normal serum phosphorus in at least three ways: (1) increased renal phosphate excretion; (2) stimulation of PTH, which also increases renal phosphate excretion; and (3) suppression of the formation of 1,25(OH)2D3, leading to diminished phosphorus absorption from the GI tract. Interestingly, high levels of FGF-23 are also an independent risk factor for left ventricular hypertrophy and mortality in CKD, dialysis, and kidney transplant patients. Moreover, elevated levels of FGF-23 may indicate the need for therapeutic intervention (e.g., phosphate restriction), even when serum phosphate levels are within the normal range. | 檢舉 |
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