46. Asbestos is a material that was once..-阿摩線上測驗
1F Peipool 高三上 (2021/03/18)
Inhaled asbestos is usually handled by alveolar macrophages. The following cellular and molecular events then occur. (1) Capture of silica/asbestos by macrophages and entrapment within lysosomes. (2) Activation of NLRP3 inflammasome to cleave procaspase 1 to an active form. (3) Cleavage of prointerleukin (IL)-1β to an active form for release to form fibrotic nodules. (4) Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the macrophages. (5) Induction of cellular and tissue damage due to the production of ROS and RNS. (6) Apoptosis of the alveolar macrophages.... 查看完整內容 |