2. The fundamental differences between RNA and DNA are
(A) the organic bases only
(B) bases, ribose units, and the phosphodiester linkage
(C) bases, ribose units, and the glycosidic bond type
(D) bases and the ribose units only

1. Which of the following is the most distinguishing difference between a purine and a pyrymidine (A) purines are found in DNA while pyrimidines are found in RNA (B) purines have nitrogens in the rings while pyrimidines do not (C) pyrimidines have nitrogens in the rings while purines do not (D) purines are found in RNA while pyrimidines are found in DNA (E) purines are double ring structures while pyrimidines have a single ring

3. Which contains a phosphoanhydride bond? (A) DNA (B) RNA (C) ATP (D) AMP (E) None of these

4. Which of the following best describes the structure of a nucleosome? (A)DNA wrapped around an octomer containing two each of H2A, H2B, H3, and H4 with H1 on the outside. (B)DNA wrapped around an octomer of H1 with H2A,B, H3 & H4 on the outside. (C)DNA wrapped around a octomer of either H2A/H2B or H3/H4 with H1 on the outside. (D)DNA wrapped around a tetramer of either H2A/H2B or H3/H4 with H1 on the outside. (E) None of these

5. Which of the following sequences of DNA is most likely to form Z-DNA? (A) (B) (C) (D)

6. The human genome is though to have about how many genes? (A)10,000 (B) 25,000 (C) 50,000 (D)100,000 (E) None of these is close to the estimate

7. Which of the following RNAs is the least abundant in a typical cell? (A)mRNA (B) rRNA (C) snRNA (D)tRNA

8. The following types of RNA are common to all organisms, except: (A)mRNA (B) rRNA (C) snRNA (D)tRNA (E) All types are found in all organisms.

9. The following enzyme is responsible for the bulk of DNA synthesis during replication. (A)DNA Polymerase I (B) DNA Polymerase II (C) DNA Polymerase III (D)DNA Polymerases IV (E) All four can make lots of DNA rapidly.

10. In E. coli, (A)the leading strand is synthesized in one piece while the lagging strand is synthesized discontinuously. (B) the leading strand is synthesized discontinuously while the lagging strand is synthesized in one piece. (C) both the leading and lagging strands are synthesized in one piece. (D)both the leading and lagging strands are synthesized discontinuously.

11. Which of the following activities does E. coli DNA polymerase III lack? (A)5' → 3' polymerase (B)5' → 3' exonuclease (C)3' → 5' exonuclease (D)E. coli DNA polymerase III has ALL of the above activities.

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