專技 - 藥理學與藥物化學題庫下載題庫

有興趣的可以閱讀論文裡關於此圖的說明喔~放在下面

The shaded area highlights the hydroxamic acid core of

hydroxyurea. Hydroxamic acids avidly bind heavy metals

and inactivate a variety of enzymes. Hydroxyurea

inhibits the iron-containing enzyme ribonucleotide reductase,

thereby killing cycling cells. Hydroxyurea also

produces nitric oxide and stimulates the heme-iron–

containing enzyme guanylate cyclase. Both activities

have the potential to increase F-cell production.

來源：
Platt, O. S., M.D. (2008). Hydroxyurea for the treatment of sickle cell anemia. The New England Journal of Medi...

有興趣的可以閱讀論文裡關於此圖的說明喔~放在下面

The shaded area highlights the hydroxamic acid core of

hydroxyurea. Hydroxamic acids avidly bind heavy metals

and inactivate a variety of enzymes. Hydroxyurea

inhibits the iron-containing enzyme ribonucleotide reductase,

thereby killing cycling cells. Hydroxyurea also

produces nitric oxide and stimulates the heme-iron–

containing enzyme guanylate cyclase. Both activities

have the potential to increase F-cell production.

來源：
Platt, O. S., M.D. (2008). Hydroxyurea for the treatment of sickle cell anemia. The New England Journal of Medicine, 358(13), 1362-9. doi:http://dx.doi.org/10.1056/NEJMct0708272