25. How Ca++ can increase the enzymatic activity of phosphorylase for glycogen metabolism? (A) Ca++ increases the activity of calmodulin-dependent protein kinase and then activate the enzymatic activity of phosphorylase (B) Ca++ increases the activity of calmodulin-dependent phosphatase and then activate the enzymatic activity of phosphorylase (C) Ca++ increases the activity of calmodulin-dependent protein kinase and then regulates glycogen synthase kinase activity, leading to up-regulation of phosphorylase activity (D) Ca++ binds to the 8 subunit of the phosphorylase kinase and then promotes the activity of phosphorylase (E) Ca++ inhibits the protein phosphatase 1 and increases increases the activity of calmodulin-dependent phosphatase and then the enzymatic activity of phosphorylase.