26.下列何者可抑制鈣離子進入mast cell而抑制細胞釋放發炎物質?
(A)guaifenesin
(B)bromhexine
(C)theobromine
(D)cromolyn

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統計: A(199), B(214), C(200), D(2280), E(0) #1739297

詳解 (共 6 筆)

#2911673
藥理第二版P.179是寫說:Cromol...
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肥大細胞穩定劑:通常為人類過敏性氣喘用藥...
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#4848816
(D) cromolyn 打開氯離子通道...
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肥大細胞穩定劑:包括有cromolyn ...
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#4036990

https://en.wikipedia.org/wiki/Cromoglicic_acid 

It is known to somewhat inhibit chloride channels (37% ± 7%)[9] and thus may inhibit the:

  • exaggerated neuronal reflexes triggered by stimulation of irritant receptors on sensory nerve endings (e.g. exercise-induced asthma)
  • release of preformed cytokines from several type of inflammatory cells (T cellseosinophils) in allergen-induced asthma

Note: Another chemical (NPPB: 5-nitro-2(3-phenyl) propylamino-benzoic acid) was shown, in the same study, to be a more effective chloride channel blocker.

Finally it may act by inhibiting calcium influx.

 

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#2927341
P.325
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綠皮P179寫cromolyn sodi...
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