內科專科醫生題庫下載題庫

1. DLBCL consists of a diffuse proliferation of large, atypical lymphocytes with a high proliferative index. These cells typically express the B-cell antigens CD19, CD20, and CD79a. Expression of CD10 and BCL6 is consistent with the tumor cell being of germinal center origin 

2. BCL2 is overexpressed in anywhere from 25 to 80% of DLBCL, whereas BCL6 is positive in more than two-thirds of cases, either as the result of translocations, gain of copy number, or promoter mutations. MYC is rearranged in 10% of DLBCLs, and ~20% of MYC-rearranged cases have concurrent BCL2 or BCL6 rearrangements, a combination referred to as “double-hit lymphoma.” These double-hit lymphomas are associated with an extremely poor prognosis with a median OS of only 12–18 months.