專技 - 藥理學與藥物化學題庫下載題庫

我找了一篇BJA期刊，有興趣可以看看

https://www.bjanaesthesia.org/article/S0007-0912(18)30061-8/fulltext

Protamine is a highly positively charged peptide consisting of about 32 amino acids, and neutralises the effect of heparin through electrostatic binding between the cationic arginine groups of protamine and the anionic heparin in a 1:1 ratio. The resulting neutral protamine–heparin salt aggregates are clearly visible as white suspension and are formed within seconds. In parallel, the binding of protamine to heparin dissociates the anti-thrombin/heparin complex, leading to the recovery o...

我找了一篇BJA期刊，有興趣可以看看

https://www.bjanaesthesia.org/article/S0007-0912(18)30061-8/fulltext

Protamine is a highly positively charged peptide consisting of about 32 amino acids, and neutralises the effect of heparin through electrostatic binding between the cationic arginine groups of protamine and the anionic heparin in a 1:1 ratio. The resulting neutral protamine–heparin salt aggregates are clearly visible as white suspension and are formed within seconds. In parallel, the binding of protamine to heparin dissociates the anti-thrombin/heparin complex, leading to the recovery of the original anti-thrombin activity. The neutralisation of heparin by protamine is further influenced by platelet factor 4 (PF4), a heparin-binding protein excreted by activated platelets. PF4 is complimentary to protamine regarding heparin neutralisation, and during extracorporeal circulation, PF4 release contributes to the stability of the protamine–heparin complex.