試題詳解

31. Re-replication during S phase results in DNA damage and genomic instability. Which one does NOT prevent the origin re-replication during DNA replication?
(A) ORC, CDC6, CDT1, and MCM are the origin licensing factors.
(B) Geminin directly binds to CDT1 to inhibit its licensing activity.
(C) Dephosphorylation of pre-RC complex, MCM, ORC1, CDC6, and CDT1, represses reactivation of origins.
(D) Cullin-based E3 ligases mediate the degradation of ORC1 and CDT1.
(E) APC/C targets the degradation of CDC6 and CDT1