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Functional Epo receptors are not only expressed on erythroid precursors, but also on megakaryocytes, vascular smooth muscle cells, endothelial cells, skeletal myoblasts, neurons, nephrons and cardiac myocytes The observation that Epo treatment increases platelet count reflects stimulation of megakaryocytopoiesis that have been observed in mice treated with high-dose, short-term Epo.   Reference: Demetz, G., Laux, M., Scherhag, A., Hoekstra, T., Suttorp, M. M., Dekker, F., Roest, M., Marcus-Kalish, M., Mittelman, M., & Ott, I. (2014). The influence of Erythropoietin on platelet activation,...
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