4. Which of the following statement concerning “animal models of pain” is least likely?
(A) When applying Von Frey filaments for identifying mechanical hyperalgesia, one of the
drawbacks is that different application speed may generate different forces.
(B) The writhing test is frequently referred to as a somatic pain model.
(C) The injection of capsaicin is thought to activate TRPV1-expression nociceptors.
(D) The injection of Freund’s complete adjuvant (FCA, or CFA) is a model for inflammatory
pain.
(E) The chronic constriction injury (CCI) model is a partial nerve lesion model.