46. Which of the following statements regarding morphine is true?
(A) Its metabolite, morphine-3-glucuronide, is a potent analgesic.
(B) In patients with renal failure, morphine-3-glucuronide may be accumulated and
induce stronger analgesic effects.
(C) Morphine is absolutely contraindicated in non-cancer pain management.
(D) The constipation induced by morphine treatment can be reversed by naloxone