35. Concerning the pathway for ketone body synthesis, all of the following make sense except
(A) Three acetyl-CoA molecules can become HMG-CoA.
(B) HMG-CoA is used for cholesterol and ketone body synthesis.
(C) HMG-CoA lyase produces acetoacetate and acetyl-CoA.
(D) Acetoacetate is oxidized to beta-bydroxybutyrate and acetone.
(E) The rate of ketone body production is proportional to the excess acety! CoA in the mitochondria.

31. Steroid hormone response elements (HREs) are_____，which, when bound to_______， alter gene expression at the level of_______. (A)intron sequences； activated hormone receptor； translation (B) nuclear proteins； hormone； transcription (C) plasma membrane proteins； hormone； transcription (D) sequences in DNA； receptor-hormone complex； replication (E) sequences in DNA； receptor-hormone complex； transcription

32. For enzymes in which the slowest (rate-limiting) step is the reactionKm becomes equivalent to: (A) kcat. (B) the [S] where V0 = Vmax. (C) the dissociation constant, Kd, for the ES complex. (D) the maximal velocity. (E) the turnover number.

33. Which of the following statements about glycolysis is correct?(1) Conversion of glucose to glyceraldehyde-3-phosphate is an endergonic reaction.(2) In the conversion of glucose-6-phosphate to fructose-6-phosphate, the C-1 aldehyde of glucose-6-phosphate is reduced to a hydroxyl group.(3) Conversion of dihyroxyacetone phosphate to glyceraldehyde-3-phosphate is an isomerization reaction. (A) 1 and 2 (B) 1 and 3 (C) 2 and 3 (D) None of above is correct. (E) All of above are correct.

34. Which of the following statements about the following reaction is correct?Citrate + COA-SH + ATP → Acetyl-CoA + Oxaloacetate + ADP + Pi(1) The reaction is catalyzed by ATP citrate lyase.(2) Formation of acetyl-CoA in this reaction provides the starting materials for lipid metabolism.(3) Formation of oxaloacetate in this reaction provides an indirect means for the production of the NADPH for lipid metabolism. (A) 1 and 2 are correct. (B) 1 and 3 are correct. (C) 2 and 3 are correct. (D) All of above are correct. (E) None of above is correct.

36. Which of the following statement(s) is correct regarding the regulation of fatty acid synthesis and breakdown?(1) Malonyl-CoA is the key repressor for fatty acid degradation due to the inhibition of fatty acid entry into mitochondria.(2) Insulin signaling triggers the dephosphory lation of acetyl-CoA carboxylase to synthesize malonyl-CoA. (3) The reaction catalyzed by fatty acid synthase is the rate-limiting step in the biosynthesis of fatty acids. (B) 2 and 3 (C) 1 and 3 (E) All of above are correct. (A) 1 and 2 (D)2 only

37. The synthesis of 1 molecule of cholesterol requires________ molecule of isopentenyl pyrophosphate , with each molecules of isopenteny1 pyrophosphate requiring________ molecules of acetyl-CoA. (A) 4；3 (B) 5；2 (C) 6；3 (D) 6；2(E) 7；3

複選題38. The urea cycle and citric acid cycle are linked by (A) arginine and fumarate. (B) citrulline and ornithine. (C) fumarate and aspartate.(D) ornithine and arginine. (E) citrulline and argininosuccinate.

39. Approximately how many ATP molecules are netted from the complete oxidation of stearic acid (C-18)? (A)2 (B)4 (C) 32 (D) 88 (E) 120

40. Gout is caused by high levels of uric acid. What are the possible causes? (A) Glucose-6-phosphatase deficiency (B) Phosphoribosylpyrophosphate (PRPP) synthetase mutation (C) Hypoxanthine-guanine phosophoribosyltransferase (HGPRT) deficiency (D) All of these are possible causes. (E) None of the above.

複選題41. What situation is most likely to cause the formation of ketone bodies?(1) Starvation (2) Gout (3) High in lipid diet (4) Regular meal(5) High in carbohydrate diets (6) Diabetes(7) Exercising (8) Intake of short-chain fatty acids (B) 3, 4, and 7 (C) 5, 6, and 7 (D) 2, 4, and 8 (A) 1,2, and 3 (E) 1, 6, and 8