38. In amino acid catabolism, the first reaction for many amino acids is a(n):
(A) oxidative deamination requiring .
(B) hydroxylation requiring NADPH and O₂.
(C) transamination requiring pyridoxal phosphate (PLP).
(D) reduction requiring pyridoxal phosphate (PLP).
(E) decarboxylation requiring thiamine pyrophosphate (TPP).

34. There is reciprocal regulation of glycolytic and gluconeogenic reactions interconverting fructose-6-phosphate and fructose-1,6-bisphosphate. Which one of the following statements about this regulation is   not   correct? (A) Fructose-2,6-bisphosphate activates phosphofructokinase-1. (B) Fructose-2,6-bisphosphate inhibits fructose-1,6-bisphosphatase. (C) The fructose-1,6-bisphosphatase reaction is exergonic. (D) The phosphofructokinase-1 reaction is endergonic. (E) This regulation allows control of the direction of net metabolite flow through the pathway.

35. Gluconeogenesis must use "bypass reactions" to circumvent(規避、繞行) three reactions in the glycolytic pathway that are highly exergonic and essentially irreversible. Reactions carried out by which three of the enzymes listed must be bypassed in the gluconeogenic pathway? 1. Hexokinase 2. Phosphoglycerate kinase 3. Phosphofructokinase-14. Pyruvate kinase 5. Triosephosphate isomerase (A) 1, 2, and 4. (B) 1, 2, and 3. (C) 1, 3, and 4. (D) 1, 4, and 5. (E) 2, 3, and 4.

36. The reaction of the citric acid cycle that is most similar to the pyruvate dehydrogenase complex-catalyzed conversion of pyruvate to acetyl-CoA is the conversion of: (A) citrate to isocitrate. (B) fumarate to malate. (C) malate to oxaloacetate. (D) succinyl-CoA to succinate. (E) α-ketoglutarate to succinyl-CoA.

37. Which of these statements about the membrane proteins is   true  ? (A) An integral membrane protein can be extracted with a chelating agent that removes divalent cations. (B) Peripheral membrane proteins are generally noncovalently bound to membrane lipids. (C) Carbohydrate moieties of membrane glycoproteins are linked to the intracellular domain of the proteins. (D) Peripheral membrane proteins may have functional units on both sides of the membrane. (E) Glycosylphosphatidylinositols, abbreviated GPI, are complex glycolipids that attach some proteins to the cytosolic surface of the plasma membrane.

39. Which of the following is   not   true about cyclic electron flow of photophosphorylation? (A) Cyclic electron flow produces more NADPH per photon than noncyclic electron flow. (B) Cyclic electron flow involves only photosystem I. (C) Plastocyanin is required for cyclic electron flow. (D) Cyclic electron flow leads to the build-up of a proton gradient. (E) Cyclic electron flow does not produce O2.

40. Which of the following statements about mitochondrial transport systems is correct? (A) Malate-aspartate shuttle: converts cytosolic NADH to mitochondrial FADH2. (B) ATP-ADP translocase: transfers ATP and a proton from matrix to cytosol while transferring ADP from cytosol to matrix. (C) Glycerophosphate shuttle: converts cytosolic FADH2 to mitochondrial NADH. (D) The malate-aspartate shuttle is irreversible while the glycerophosphate shuttle is reversible. (E) None of the above are correct.

複選題41. A characteristic of the glycerophosphate shuttle is: (A) It shuttles NADH across the mitochondrial membrane to yield 2.5 ATP/ADH. (B) It shuttles "NADH electron equivalents" across the mitochondrial membrane to yield 1.5 ATP/NADH. (C) It only operates efficiently when the [NADH] in the cytoplasm is higher than in the matrix. (D) Malate is a key component in the shuttle process. (E) Aspartate is a key component in the shuttle process.

42. Which of the following correctly and completely describes electron movement in electron transport? (A) NADH → complex I → complex III → coenzyme Q→ Complex IV → O2 (B) [FADH2] → complex II → cytochrome c → complex III → coenzyme Q → Complex IV → O2 (C) NADH → complex I → coenzyme Q→ complex III -~-→ cytochrome c → Complex IV → O2 (D) [FADH2] → complex I → coenzyme Q→ complex III → Complex IV → O2 (E) None of the above

43. Glutamine synthetase plays an important role in the incorporation of ammonia (or ammonium ions) into glutamine. Which of the following mechanisms of covalent modification controls the activity of glutamine synthetase? (A) Phosphorylation/dephosphorylation. (B) Adenylation/deadenylation. (C) Acetylation/deacetylation. (D) Methylation/demethylation. (E) None of the above.

44. Most cancers depend on a high rate of aerobic glycolysis for their continued growth and survival. Paradoxically, some cancer cell lines also display addiction to glutamine. Which of the following is   not   true for the possible mechanism behind this glutamine addiction: (A) Glutamine is an essential amino acid. (B) Glutamine provides nitrogen for nucleotide synthesis. (C) Glutamine provides substrate for mitochondrial citric acid cycle. (D) Glutamine provides nitrogen for protein synthesis. (E) Glutamine activates mTORC1 signaling.