試題詳解

4. Which of following description about non-steroidal anti-inflammatory drugs (NSAIDs) pharmacology is "Correct"?
(A) NSAIDs work by inhibiting the inflammation associated enzyme cyclooxygenase and lipoxygenase
(B) Perioperative use of NSAIDs will not increase the risk of surgical site bleeding
(C) NSAIDs will not have drug-drug interaction with anticoagulant (such as warfarin)
(D) Cyclooxygenase-2 (Cox-2) is the inducible isoform of cyclooxygenase but is constitutively expressed in certain tissues such as brain and kidney
(E) Compared with non-selective NSAIDs, long term use of Cox-2 inhibitors will significantly reduce the risk of serious cardiovascular events, renal failure or congestive heart failure.