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65 下列屬於 Triptans 類之藥品中，何者與 CYP3A4 抑制劑具有最顯著之交互作用，應避免合併使用？
(A) Eletriptan
(B) Rizatriptan
(C) Zolmitriptan
(D) Frovatriptan

專技 - 藥物治療學- 101 年 - 101-1 專技高考_藥師：藥物治療學#9919

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討論
私人筆記( 2 )

最佳解!
	海星高一下 (2014/07/26) (A) Eletriptan：3A4 排除(B) Rizatriptan：MAO-A 排除(C) .....觀看完整全文，請先登入檢舉

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	3F 炸雞翅大一上 (2020/07/20) 記：Eletriptan 的E像是★★★★... (內容隱藏中) 查看隱藏文字
	4F Tegralition (2022/06/12) Inhibitors of cytochrome P-450 (CYP) 3A4 reduce the clearance of almotriptan and eletriptan. For almotriptan, increased exposure to triptans should be anticipated; however, no specific dosing adjustments are proposed. The interaction between eletriptan and CYP 3A4 inhibitors is more significant, and particular precautions are necessary. Eletriptan should not be used within 72 hours of treatment with potent CYP 3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir). Applied 10e p134... 查看完整內容 Inhibitors of cytochrome P-450 (CYP) 3A4 reduce the clearance of almotriptan and eletriptan. For almotriptan, increased exposure to triptans should be anticipated; however, no specific dosing adjustments are proposed. The interaction between eletriptan and CYP 3A4 inhibitors is more significant, and particular precautions are necessary. Eletriptan should not be used within 72 hours of treatment with potent CYP 3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir). Applied 10e p1345 檢舉
	5F 洪峻澤大三上 (2023/07/11) Triptan類PK/PD考點補充： 1.二代Triptan口服BA皆優於sumatriptan (除了sumatriptan的Triptan都是二代) 2.二代Triptan口服劑型為主，zolmitriptan除了口服還有鼻噴 3.sumatriptan可以口服、SC、鼻噴，SC的BA最好 4.sumatriptan半衰期短 (2小時) 5.二代Triptan中，frovatriptan半衰期最長 (25小時) 6.naratriptan較少有CYP相關的交互作用 7.CYP3A4代謝：eletriptan(最顯著)、almotriptan 檢舉

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