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ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, replacing the older MOPP protocol. It consists of concurrent treatment with the chemotherapy drugs:

CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of:

ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, replacing the older MOPP protocol. It consists of concurrent treatment with the chemotherapy drugs:

• Adriamycin (also known as doxorubicin/hydroxydaunorubicin, designated as H in CHOP)
• Bleomycin
• Vinblastine
• Dacarbazine (similar to procarbazine, designated as P in MOPP and in COPP)

CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of:

• (C)yclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links
• (H)ydroxydaunorubicin (also called doxorubicin or adriamycin), an intercalating agent which damages DNA by inserting itself between DNA bases
• (O)ncovin (vincristine), which prevents cells from duplicating by binding to the protein tubulin
• (P)rednisone or (P)rednisolone, which are corticosteroids.

Sometimes the chimeric anti-CD20 monoclonal antibody, rituximab, is added to this treatment regimen to form the R-CHOP regimen.

MOPP is a combination chemotherapy regimen used to treat Hodgkin lymphoma. The acronym is derived from the component drugs of the regimen:

• (M)ustargen (also known as mechlorethamine, chlormethine, mustine, nitrogen mustard, or MSD)
• (O)ncovin (also known as Vincristine or VCR)
• (P)rocarbazine (also known as Matulane or Natulan)
• (P)rednisone (also known as Deltasone or Orasone)

The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin lymphoma treatment is ABVD.

C-MOPP involves switching the nitrogen mustard from mechlorethamine to cyclophosphamide. C-MOPP is thus very similar to COPP, using the same 4 agents and differing at most in dosages and timing.