專技 - 藥物治療學題庫下載題庫

本藥會抑制嗜伊紅性白血球和淋巴球的產生，但是卻會刺激紅血球及多形核白血球的產生。發炎過程及其後的傷口癒合階段則會被抑制。

機制：

（白話文就是讓黏在血管壁上的白血球開始流竄全身）

Because steroid medications are analogues of glucocorticoid hormones. 

Hormones are signalling molecules. 

Glucocorticoids, e.g. cortisol, have a variety of physiological effects, and one of those effects is to increase the 　　number of circulating WBC — actually one specific type of WBC, neutrophils. 

Normally you have a lot neutrophils that hang out on the inner lining of blood vessels… they actually stick...

本藥會抑制嗜伊紅性白血球和淋巴球的產生，但是卻會刺激紅血球及多形核白血球的產生。發炎過程及其後的傷口癒合階段則會被抑制。

機制：

（白話文就是讓黏在血管壁上的白血球開始流竄全身）

Because steroid medications are analogues of glucocorticoid hormones. 

Hormones are signalling molecules. 

Glucocorticoids, e.g. cortisol, have a variety of physiological effects, and one of those effects is to increase the 　　number of circulating WBC — actually one specific type of WBC, neutrophils. 

Normally you have a lot neutrophils that hang out on the inner lining of blood vessels… they actually stick there, so they don’t actually enter into the bloodstream. 

Cortisol downregulates the expression of the cell adhesion proteins that make the neutrophils stick to the vessel  lining, causing them to “demarginate”, i.e. let go, and thereby actually start circulating in the blood.