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methimazole
Hyperthyroidism Initial: Mild hyperthyroidism: 5 mg orally every 8 hours. Moderately severe hyperthyroidism: 10 mg orally every 8 hours (up to 40 mg per day). Severe hyperthyroidism: 20 mg orally every 8 hours.
Maintenance: 5 to 15 mg orally daily.

Methimazole Pregnancy Warnings

Methimazole has been assigned to pregnancy category D by the FDA. Methimazole readily crosses the placental membranes and can induce goiter and cretinism in the developing fetus.

The risk is especially high during first trimester (during organogenesis).

The manufacturer recommends using th...

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methimazole

Hyperthyroidism

Initial:

Mild hyperthyroidism: 5 mg orally every 8 hours.

Moderately severe hyperthyroidism: 10 mg orally every 8 hours (up to 40 mg per day).

Severe hyperthyroidism: 20 mg orally every 8 hours.

Maintenance:

5 to 15 mg orally daily.

Methimazole Pregnancy Warnings

Methimazole has been assigned to pregnancy category D by the FDA. Methimazole readily crosses the placental membranes and can induce goiter and cretinism in the developing fetus.

The risk is especially high during first trimester (during organogenesis).

The manufacturer recommends using the lowest dose possible if methimazole is used during pregnancy.

Propylthiouracil is typically the preferred agent in pregnancy as is crosses the placenta to a lesser degree.