藥物化學與生藥學題庫下載題庫

(B)Canrenone is an active metabolite of spironolactone with a long half-life, which is currently available only in Europe. Canrenone has been shown to improve diastolic function in patients with primary hypertension independently of effects on BP and LV mass regression, suggesting a direct myocardial effect.

https://www.medscape.com >

Spironolactone 是 Aldosterone 的直接性拮抗劑。
Canrenone為活代謝物。
Lactone 內酯 位於 C17上。
Spiro：兩個環只由一個點連在一起。