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The management of tumor lysis syndrome, other than hydration and alkalinization, necessitates the administration of drugs to correct metabolic disturbances. Use of these medications should be instituted before the start of chemotherapy; the goal is to achieve optimal metabolic stability. Medications can be adjusted after the start of chemotherapy in response to the level of tumor lysis and/or metabolic disturbances.
Allopurinol, a xanthine oxidase inhibitor, reduces the conversion of nucleic acid byproducts to uric acid, in this way preventing urate nephropathy and subsequent oliguric renal f...
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The management of tumor lysis syndrome, other than hydration and alkalinization, necessitates the administration of drugs to correct metabolic disturbances. Use of these medications should be instituted before the start of chemotherapy; the goal is to achieve optimal metabolic stability. Medications can be adjusted after the start of chemotherapy in response to the level of tumor lysis and/or metabolic disturbances.

Allopurinol, a xanthine oxidase inhibitor, reduces the conversion of nucleic acid byproducts to uric acid, in this way preventing urate nephropathy and subsequent oliguric renal failure.An alternative to allopurinol for decreasing uric acid load is rasburicase (urate oxidase), which controls hyperuricemia by converting uric acid to water-soluble allantoin.

Ref:https://emedicine.medscape.com/article/282171-medication