43. Which of the following statement concerning “joint pain” is least likely?
(A) In a normal joint, only intense pressure on the joint and movements exceeding the working
range elicit pain.
(B) Under pathological conditions such as joint inflammation, hypersensitivity of the nociceptive
system occurs frequently and leads to pain on palpation.
(C) Mechanical sensitization of joint nociceptors is generated by numerous inflammatory
mediators, including prostaglandins and cytokines.
(D) Spinal sensitization involves excitatory amino acids, neuropeptides, and spinal prostaglandins.
(E) Better understanding of pain mechanisms can't improve pain therapy.
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