44. In a number of species calorie restriction without malnutrition may slow the biological aging process, resulting in longer maintenance of youthful health and an increase in both median and maximum lifespan. Which of the followings is involved in the underlying mechanism?
(A) Decrease in body weight.
(B) Inhibition of AMPK.
(C) Activation of sirtuin.
(D) Activation of mTOR.
(E) Inhibition of autophagy.
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