46. How easily do you break a bone? __________ (1) As a result, sales of drugs treating osteoporosis totaled some \$7 billion last year. (2) “Up to half of women over age 50 will break a bone due to osteoporosis in their lifetime.” (3) Consumers likely have heard such claims hundreds of times in commercials for drugs to treat osteoporosis, a bone-thinning disease primarily afflicting women. (4) The medical community is nevertheless hardly of one mind about how many women over 50 should be taking these drugs. (A) 2 4 1 3 (B) 3 4 1 2 (C) 2 3 1 4 (D) 4 2 1 3

49. Replacing a circuit breaker in a dark basement is one thing. __________ (1) It will perform many of the station's mundane tasks and reduce the number of death-defying spacewalks. (2) But what if you had to climb around the outside of a spacecraft orbiting hundreds of miles above the Earth to do it? (3) Fortunately, help is scheduled to arrive this month in the form of the Special Purpose Dexterous Manipulator, a versatile, \$200-million robotic handyman. (4) This kind of dangerous maintenance work has become fairly common for astronauts aboard the International Space Station, where they spend as much time fixing the \$100-billion-plus orbiting science lab as they spend performing actual research. (A) 2 4 3 1 (B) 4 1 2 3 (C) 3 2 1 4 (D) 2 3 1 4

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