48. In the glycolytic pathway, there is an isomerization of glucose 6-phosphate to fructose 6-phosphate ocours two steps before the C-C bond cleavage reaction between C3 and C4 to produce two three-carbon sugars. Where would the bond cleavage occur if there is no preceding isomerization? (A) Without isomerization, bond cleavage would occur between C2 and C3. (B) Without isomerization, bond cleavage would occur between C3 and C4. (C) Without isomerization, bond cleavage would occur between C4 and CS. (D) Without isomerization, bond cleavage would occur between C5 and C6. (E) Without isomerization, bond cleavage would occur between C1 and C2.