49. In normal mitochondria, the rate of NADH consumption (oxidation) will: (A) Be increased in active muscle, and decreased in inactive muscle. (B) Be very low if the ATP synthase is inhibited, but increase when an uncoupler is added. (C) Decrease if mitochondrial ADP is depleted. (D) Decrease when cyanide is used to prevent electron transfer through the cytochrome a and a3 complex. (E) All ofthe above are true.

1. Compare the two reaction coordinate diagrams below and select the answer that correctly describes their relationship. In eachcase, the single intermediate is the ES complex.Free energy, (A) Diagram (a) describes a strict "lock and key" model, whereas diagram (b) describes a transition-state complementarity model. (B) The activation energy for the catalyzed reaction is #5 in diagram (a) and is #7 in diagram (b). (C) The activation energy for the uncatalyzed reaction is given by #5 + #6 in diagram (a) and by #7 + #4 in diagram (b). (D) The contribution of binding energy is given by #5 in diagram (a) and by #7 in diagram (b). (E) The ES complex is given by #2 in diagram (a) and #3 in diagram (b).

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