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7 Clorazepate 在胃中會進行脫羧（decarboxylation）反應，所得產物與以下何藥物之主要代謝物相同？
(A) Diazepam
(B) Lorazepam
(C) Flurazepam
(D) Loprazolam

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難度： 簡單
1F
Bryan 國三上 (2014/04/05)
Clorazepate (marketed under the brand names Tranxene and Novo-Clopate), also known as clorazepate dipotassium, is a drug that is a benzodiazepine derivative
Since orally administered Clorazepate dipotassium is rapidly decarboxylated to form (nordiazepam), there is essentially no circulating parent drug. Nordiazepam, the primary metabolite, quickly appears in the blood and is eliminated from the plasma with an apparent half-life of about 40 to 50 hours. 
2F
Bryan 國三上 (2014/06/11)
Clorazepate is a prodrug for desmethyldiazepam, which is rapidly produced as an active metabolite. Desmethyldiazepam is responsible for most of the therapeutic effects of clorazepate.73756978.png#s-234,200


7 Clorazepate 在胃中會進行脫羧（decarboxylation）反..-阿摩線上測驗